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Risk Factors:

Contraindications: Hypersensitivity to ketoconazole. Acute or chronic liver disease; concurrent use with ALPRAZolam colchicine dofetilide dronedarone eplerenone ergot derivatives irinotecan lurasidone methadone midazolam (oral) pimozide quiNIDine ranolazine statins tolvaptan triazolam.Pregnancy/Lactation: Oral form distributed in breast milk. Unknown if Topical form crosses placenta or is distributed in breast milk. Children: Cream shampoo: Safety and efficacy not esTabletlished. Oral form: Safety and efficacy not esTabletlished in pts younger than 2 yrs. Elderly: No age-related precautions noted.

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Indications:

PO: Treatment of susceptible fungal infections including histoplasmosis
blastomycosis coccidioidomycosis paracoccidioidomycosis chromomycosis.
Shampoo: Treatment of dandruff. Treatment of tinea versicolor. Topical:
Treatment of tineas pityriasis versicolor cutaneous candidiasis seborrhea
dermatitis dandruff. Xolegel: Treatment of seborrheic dermatitis. OFFLABEL:
PO: Treatment of advanced prostate cancer.

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Adverse Effects:

Occasional (10%?3%): Nausea vomiting. Rare (less than 2%): Abdominal
pain diarrhea headache dizziness photophobia. Topical: Burning irritation
pruritus.
Adverse effects/toxic reactions
Hematologic toxicity (thrombocytopenia hemolytic anemia leukopenia) occurs
occasionally. Hepatotoxicity may occur within first wk to several mos after
starting therapy. Anaphylaxis occurs rarely

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Don’t Use:

Hepatic impairment concomitant use of drugs decreasing gastric acidity (e.g.
antacids H2 antagonists proton pump inhibitors) adrenal insufficiency.