Ketone 200 mg oral
Contraindications: Hypersensitivity to ketoconazole. Acute or chronic liver disease; concurrent use with ALPRAZolam colchicine dofetilide dronedarone eplerenone ergot derivatives irinotecan lurasidone methadone midazolam (oral) pimozide quiNIDine ranolazine statins tolvaptan triazolam.Pregnancy/Lactation: Oral form distributed in breast milk. Unknown if Topical form crosses placenta or is distributed in breast milk. Children: Cream shampoo: Safety and efficacy not esTabletlished. Oral form: Safety and efficacy not esTabletlished in pts younger than 2 yrs. Elderly: No age-related precautions noted.
PO: Treatment of susceptible fungal infections including histoplasmosis
blastomycosis coccidioidomycosis paracoccidioidomycosis chromomycosis.
Shampoo: Treatment of dandruff. Treatment of tinea versicolor. Topical:
Treatment of tineas pityriasis versicolor cutaneous candidiasis seborrhea
dermatitis dandruff. Xolegel: Treatment of seborrheic dermatitis. OFFLABEL:
PO: Treatment of advanced prostate cancer.
Occasional (10%?3%): Nausea vomiting. Rare (less than 2%): Abdominal
pain diarrhea headache dizziness photophobia. Topical: Burning irritation
Adverse effects/toxic reactions
Hematologic toxicity (thrombocytopenia hemolytic anemia leukopenia) occurs
occasionally. Hepatotoxicity may occur within first wk to several mos after
starting therapy. Anaphylaxis occurs rarely
Hepatic impairment concomitant use of drugs decreasing gastric acidity (e.g.
antacids H2 antagonists proton pump inhibitors) adrenal insufficiency.