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Risk Factors:

Hypersensitivity to tolterodine or fesoterodine. Gastric retention uncontrolled narrow-angle glaucoma urinary retention.Pregnancy/Lactation: Unknown if drug is distributed in breast milk. Breastfeeding not recommended. Children: Safety and efficacy not esTabletlished. Elderly: No age-related precautions noted

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Indications:

Essential hypertension oedema and ascites of congestive cardiac failure cirrhosis of liver nephrotic syndrome.

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Adverse Effects:

Spironolactone: Gynaecomastia GI upset rash drowsiness headache confusion malaise benign breast neoplasm blood dyscrasias hepatic impairment electrolyte
disturbances leg cramps ataxia dizziness changes in libido confusion menstrual disorders breast pain skin reaction acute renal failure alterations in voice pitch.
Hydrochlorothiazide: Anorexia epigastric distress

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Don’t Use:

Renal impairment clinically significant bladder outflow obstruction (risk of
urinary retention) GI obstructive disorders (e.g. pyloric stenosis [risk of gastric
retention]) treated narrow-angle glaucoma myasthenia gravis prolonged QT
interval (congenital/medications hypokalemia hypomagnesemia) hepatic
impairment elderly.