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Risk Factors:

Contraindications: History of hypersensitivity/anaphylactic reaction to cefuroxime cephalosporins.Pregnancy/Lactation: Readily crosses placenta. Distributed in breast milk. Children: No age-related precautions noted. Elderly: Age-related renal impairment may require dosage adjustment.

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Indications:

Treatment of susceptible infections due to group B streptococci pneumococci
staphylococci H. influenzae E. coli Enterobacter Klebsiella including
acute/chronic bronchitis gonorrhea impetigo early Lyme disease otitis media
pharyngitis/tonsillitis sinusitis skin/skin structure UTI perioperative
prophylaxis.

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Adverse Effects:

Frequent: Discomfort with IM administration oral candidiasis (thrush) mild
diarrhea mild abdominal cramping vaginal candidiasis. Occasional: Nausea
serum sickness?like reaction (fever joint pain; usually occurs after second
course of therapy and resolves after drug is discontinued). Rare: Allergic
reaction (rash pruritus urticaria) thrombophlebitis (pain redness swelling at
Injectionection site).
Adverse effects/toxic reactions
Antibiotic-associated colitis other superinfections (abdominal cramps severe
watery diarrhea fever) may result from altered bacterial balance in GI tract.
Nephrotoxicity may occur esp. in pts with preexisting renal disease. Pts with
history of penicillin allergy are at increased risk for developing a severe
hypersensitivity reaction (severe pruritus angioedema bronchospasm
anaphylaxis).

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Don’t Use:

Severe renal impairment history of
penicillin allergy. Pts with hx of colitis GI malabsorption seizures.