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Risk Factors:

Contraindications: Hypersensitivity to moxifloxacin other quinolones.Pregnancy/Lactation: May be distributed in breast milk. May produce teratogenic effects. Children: Safety and efficacy not esTabletlished. Elderly: No age-related precautions noted.

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Indications:

Treatment of susceptible infections due to S. pneumoniae S. pyogenes S.
aureus H. influenzae M. catarrhalis K. pneumoniae M. pneumoniae C.
pneumoniae including acute bacterial exacerbation of chronic bronchitis acute
bacterial sinusitis intra-abdominal infection community-acquired pneumonia
uncomplicated skin/skin structure infections. Ophthalmic: Topical treatment of
bacterial conjunctivitis due to susceptible strains of bacteria.

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Adverse Effects:

Frequent (8%?6%): Nausea diarrhea. Occasional: PO IV (3%?2%):
Dizziness headache abdominal pain vomiting. Ophthalmic (6%?1%):
Conjunctival irritation reduced visual acuity dry eye keratitis eye pain ocular
itching swelling of tissue around cornea eye discharge fever cough
pharyngitis rash rhinitis. Rare (1%): Altered taste dyspepsia photosensitivity.
Adverse effects/toxic reactions
Pseudomembranous colitis (severe abdominal cramps/pain severe watery
diarrhea fever) may occur. Superinfection (anal/genital pruritus moderate to
severe diarrhea stomatitis) may occur. May increase risk of tendonitis tendon
rupture peripheral neuropathy.

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Don’t Use:

Renal/hepatic impairment bradycardia acute myocardial ischemia
myasthenia gravis diabetes rheumatoid arthritis seizures pts with prolonged
QT interval medications known to prolong QT interval hypokalemia
hypomagnesemia elderly pts with suspected CNS disorder pts at risk for tendon
rupture tendonitis (e.g. renal failure concomitant use of corticosteroids; solid
organ transplant recipient elderly).