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Risk Factors:

Contraindications: Hypersensitivity to levothyroxine. Acute MI untreated subclinical or overt thyrotoxicosis uncorrected adrenal insufficiency. Capsolsule: Inability to swallow Capsolsules.Pregnancy/Lactation: Does not cross placenta. Minimal distribution in breast milk. Children: No age-related precautions noted. Caution in neonates in interpreting thyroid function tests. Elderly: May be more sensitive to thyroid effects; individualized dosage recommended

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Indications:

PO: Treatment of hypothyroidism pituitary thyroid-stimulating hormone (TSH)
suppression. IV: Myxedema coma. OFF-LABEL: Management of
hemodynamically unsTabletle potential organ donors.

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Adverse Effects:

Occasional: Reversible hair loss at start of therapy in children. Rare: Dry skin
GI intolerance rash urticaria pseudotumor cerebri severe headache in children.
Adverse effects/toxic reactions
Excessive dosage produces signs/symptoms of hyperthyroidism (weight loss
palpitations increased appetite tremors anxiety tachycardia hypertension
headache insomnia menstrual irregularities). Cardiac arrhythmias occur
rarely. Long-term therapy may decrease bone mineral density.

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Don’t Use:

Cautions: Elderly pts angina pectoris
hypertension other cardiovascular disease adrenal insufficiency myxedema
diabetes mellitus and insipidus swallowing disorders