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Risk Factors:

Pregnancy: Risk cannot be ruled out. Lactation: Caution advised or effect undetermined. Contraindications: Within 2 weeks of stopping MAOls or 1 day of stopping moclobemide or linezolid.

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Indications:

Indications
All types of depressive illness depression accompanied by anxiety. Obsessive compulsive disorder. Panic disorder with or without agoraphobia. Symptoms of social
phobia.

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Adverse Effects:

GI upset decreased appetite anorexia somnolence sweating tremor headache asthaenia dly mouth dizziness blurred vision yawning abnormal dreams
insomnia agitation weight gain impaired concentration elevated cholesterol levels sexual dysfunction dystonic reactions akathisia. Rarely serotonin or neuroleptic
malignant syndrome hyponatraemia haemorrhage aggression.

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Don’t Use:

Precautions: Hepatic or severe renal (CrCl 30 mL/min) impairment serotonin syndrome cardiovascular disease bleeding disorders glaucoma epilepsy (discontinue
if new or increased seizures) ECT diabetes hyponatraemia. History of mania; discontinue if patient enters a manic phase. History of suicide-related events; monitor
for suicidal ideation. Withdraw gradually. Elderly. Dose increases may be detrimental in patients who develop akathisia.