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Risk Factors:

Contraindications: Hypersensitivity to oxybutynin. Pts with or at risk for uncontrolled narrow-angle glaucoma urinary retention gastric retention or conditions with severely decreased GI motility.Pregnancy/Lactation: Unknown if drug crosses placenta or is distributed in breast milk. Children: No age-related precautions noted in those older than 5 yrs. Elderly: May be more sensitive to anticholinergic effects (e.g. dry mouth urinary retention).

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Indications:

Relief of symptoms (urgency incontinence frequency nocturia urge
incontinence) associated with uninhibited neurogenic bladder reflex neurogenic
bladder. Extended-Release (additional): Treatment of symptoms associated
with detrusor overactivity due to neurologic disorder (e.g. spina bifida)

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Adverse Effects:

Frequent: Constipation dry mouth drowsiness decreased perspiration.
Occasional: Decreased lacrimation/salivation impotence urinary
hesitancy/retention suppressed lactation blurred vision mydriasis
nausea/vomiting insomnia.
Adverse effects/toxic reactions
Overdose produces CNS excitation (nervousness restlessness hallucinations
irriTabletility) hypotension/hypertension confusion tachycardia facial flushing
respiratory depression.

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Don’t Use:

Cautions: Renal/hepatic
impairment pts with bladder outflow obstruction treated narrow-angle
glaucoma hyperthyroidism coronary artery disease HF hypertension
arrhythmias prostatic hyperplasia myasthenia gravis reduced GI motility GI
obstructive disorder gastroesophageal reflux.