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Risk Factors:

Pregnancy: Contraindicated in pregnancy. Lactation: Contraindicated or not recommended. Contraindications: Active peptic ulcer aspirin/anti-inflammatory induced allergy or asthma. Women planning pregnancy. Severe hepatic or renal failure. Ischaemic heart disease cerebrovascular disease peripheral arterial disease CHF. Treatment of pain before CABG surgery.

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Indications:

Indications
Prophylaxis against NSAIDS induced gastric ulceration in patients requiring diclofenac sodium for rheumatoid arthritis osteoarthrosis.

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Adverse Effects:

GI upset menorrhagia intermenstrual bleeding skin reactions headache diziness oedema rash pruritus foetal malformation raised LFI's.

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Don’t Use:

Precautions: Monitor patients on Iong-term treatment. History of gastro-intestinal lesions. Renal hepatic or cardiac impairment. Cerebrovascular coronary or peripheral
disease. Pre-menopausal women should use effective contraception. Haematopoietic disorders defective coagulation or history of cerebrovascular bleeding. Severe
dehydration. Hypertension; monitor BP during and throughout therapy. Monitor liver function periodically. Monitor blood counts and renal function during long term
treatment. Use lowest effective dose for shortest duration.