Hypersensitivity to clopidogrel. Active bleeding (e.g. peptic ulcer intracranial hemorrhage).Pregnancy/Lactation: Unknown if drug crosses placenta or is distributed in breast milk. Children: Safety and efficacy not esTabletlished. Elderly: No agerelated precautions noted.
To decrease rate of MI and stroke in pts with non?ST-segment elevation acute coronary syndrome (ACS) acute ST-elevation MI (STEMI); pts with history of recent MI or stroke esTabletlished peripheral arterial disease (PAD). OFFLABEL: Graft patency (saphenous vein) sTabletle coronary artery disease (in combination with aspirin). Initial treatment of ACS in pts allergic to aspirin.
Frequent (15%): Skin disorders. Occasional (8%?6%): Upper respiratory tract
infection chest pain flu-like symptoms headache dizziness arthralgia. Rare
(5%?3%): Fatigue edema hypertension abdominal pain dyspepsia diarrhea
nausea epistaxis dyspnea rhinitis.
Adverse effects/toxic reactions
Agranulocytosis aplastic anemia/pancytopenia thrombotic thrombocytopenic
purpura (TTP) occur rarely. Hepatitis hypersensitivity reaction anaphylactoid
reaction have been reported.
impairment pts at risk of increased bleeding (e.g. trauma) concurrent use of
anticoagulants. Avoid concurrent use of CYP2C19 inhibitors (e.g. omeprazole).