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Risk Factors:

Contraindications: Hypersensitivity to piroxicam. Perioperative pain in setting of CABG surgery history of hypersensitivity to aspirin/NSAIDs active GI bleeding. Pts with aspirin triad (asthma rhinitis and aspirin intolerance).Pregnancy/Lactation: Crosses placenta; distributed in breast milk. Avoid use during third trimester (may adversely affect fetal cardiovascular system: premature closing of ductus arteriosus). Children: Safety and efficacy not esTabletlished. Elderly: Age-related renal impairment may increase risk of hepatotoxicity renal toxicity; reduced dosage recommended. More likely to have serious adverse effects with GI bleeding/ulceration.

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Indications:

Management of acute or chronic rheumatoid arthritis (RA) osteoarthritis. OFFLABEL: Treatment of juvenile idiopathic arthritis.

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Adverse Effects:

Frequent (9%?4%): Dyspepsia nausea dizziness. Occasional (3%?1%):
Diarrhea constipation abdominal cramps/pain flatulence stomatitis. Rare (less
than 1%): Hypertension urticaria dysuria ecchymosis blurred vision
insomnia phototoxicity.
Adverse effects/toxic reactions
Peptic ulcer GI bleeding gastritis severe hepatic reaction (cholestasis jaundice)
occur rarely. Nephrotoxicity (dysuria hematuria proteinuria nephrotic
syndrome) hematologic toxicity (anemia leukopenia eosinophilia
thrombocytopenia) severe hypersensitivity reaction (fever chills
bronchospasm) occur rarely with long-term treatment.

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Don’t Use:

Advanced renal disease hepatic impairment asthma
coagulation disorders concomitant use of anticoagulants poor CYP2C9
meTabletolizers. History of GI bleeding or ulcers alcohol abuse. Avoid use in late
pregnancy.