Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Aortic stenosis outflow obstruction cor pulmonale. Angioneurotic oedema related to previous ACE-inhibitor therapy. Renal dysfunction. Systolic BP <100 mmHg in acute MI.
Indications Essential and renovascular hypertension when standard treatment is ineffective or inappropriate because of adverse effects. Adjunct to diuretics and/or digitalis in congestive cardiac failure. Hypertension when used in addition to diuretic in cardiac decompensation or in volume depletion renal complications of Diabetes Mellitus.
Hypotension renal failure angioedema rash dizziness headache GI upset cough fatigue palpitations asthaenia impotence pruritus rhinitis neutropenia
agranulocytosis thrombocytopenia anaemia sleep disturbances dysgeusia hepatic failure.
Precautions: Renovascular hypertension severe congestive heart failure bilateral renal artery stenosis ischaemic heart disease cerebrovascular disease low systolic
BP in acute MI haemodialysis renal impairment; monitor renal function before and during treatment white cell count before and during therapy. Risk factors for
hypotension. Anaesthesia aortic or mitral valve stenosis outflow obstruction collagen vascular disease diabetes LDL apheresis. Monitor serum electrolytes.