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Risk Factors:

Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: Active liver disease. Depression. Catecholamine-secreting tumours (eg phaeochromocytoma paraganglioma).

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Indications:

All grades of hypertension.

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Adverse Effects:

Sedation headache asthaenia depression bradycardia nasal congestion dry mouth GI upset positive Coomb's testjaundice haemolytic anaemia.

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Don’t Use:

Precautions: Haemolytic anaemia. History of liver disorder. Monitor liver function and WBC before therapy and for first 6-12 weeks or in case of fever. Renal
impairment. Anaesthesia. Severe bilateral cerebrovascular disease. Porphyria.