Pregnancy: No evidence of risk in humans. Lactation: Caution advised or effect undetermined. Contraindications: Active liver disease. Depression. Catecholamine-secreting tumours (eg phaeochromocytoma paraganglioma).
All grades of hypertension.
Sedation headache asthaenia depression bradycardia nasal congestion dry mouth GI upset positive Coomb's testjaundice haemolytic anaemia.
Precautions: Haemolytic anaemia. History of liver disorder. Monitor liver function and WBC before therapy and for first 6-12 weeks or in case of fever. Renal
impairment. Anaesthesia. Severe bilateral cerebrovascular disease. Porphyria.