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Risk Factors:

Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem. Lactation: Contraindicated or not recommended.

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Indications:

Malaria due to plasmodium falciparum resistant or mixed infections.

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Adverse Effects:

Abdominal pain anorexia diarrhoea vomiting nausea palpitation prolonged QT interval cough headache dizziness asthaenia sleep disturbances paresthesia
arthralgia myalgia pruritus rash GI upset fatigue cough gait disturbance raised liver enzyme.

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Don’t Use:

Contraindications: History of arrhythmias clinical relevant bradycardia congestive heart failure accompanied by reduced ventricular ejection fraction; family history
of sudden death or of congenital QT interval prolongation. Severe malaria other plasmodium infections.
Precautions: Electrolyte disturbances concomitant use with other drugs known to cause QT-interval prolongation monitor patients unable to take food (greater risk
of recrudescence). Dizziness may affect performance. Severe cardiac renal or hepatic impairment; monitor ECG potassium.
Indications