Pregnancy: Contraindicated in pregnancy. Lactation: Caution advised or effect undetermined. Contraindications: Type I diabetes diabetic ketoacidosis pre-coma and coma severe renal or hepatic insufficiency. Surgely severe trauma infections. Porphyria.
Maturity-onset diabetes. Type 2 diabetes.
Hypoglycaemia GI disturbances including nausea dyspepsia diarrhoea and constipation. Skin reactions hepatic failure hepatitis jaundice blood dyscrasias.
Precautions: Children. Mild to moderate renal or hepatic impairment obesity GGPD deficiency risk factors for hypoglycaemia ( incl malnourishment severe vascular
disease adrenal or pituitary insufficiencyiency hypothyroidism).