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Risk Factors:

Contraindications: Hypersensitivity to clarithromycin other macrolide antibiotics. History of QT prolongation or ventricular arrhythmias including torsades de pointes. History of cholestatic jaundice or hepatic impairment with prior use of clarithromycin. Concomitant use with colchicine (in pts with renal/hepatic impairment) lovastatin simvastatin pimozide ergotamine dihydroergotamine. Pregnancy/Lactation: Unknown if distributed in breast milk. Children: Safety and efficacy not esTabletlished in pts younger than 6 mos. Elderly: Age-related renal impairment may require dosage adjustment.

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Indications:

Treatment of susceptible infections due to C. pneumoniae H. influenzae H. parainfluenzae H. pylori M. catarrhalis M. avium M. pneumoniae S. aureus S. pneumoniae S. pyogenes including bacterial exacerbation of bronchitis otitis media acute maxillary sinusitis Mycobacterium avium complex (MAC) pharyngitis tonsillitis H. pylori duodenal ulcer community-acquired pneumonia skin and soft tissue infections. Prevention of MAC disease. OFFLABEL: Prophylaxis of infective endocarditis pertussis Lyme disease.

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Adverse Effects:

Occasional (6%?3%): Diarrhea nausea altered taste abdominal pain. Rare
(2%?1%): Headache dyspepsia.
Adverse effects/toxic reactions
Antibiotic-associated colitis other superinfections (abdominal cramps severe
watery diarrhea fever) may result from altered bacterial balance in GI tract.
Hepatotoxicity thrombocytopenia occur rarely.

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Don’t Use:

Hepatic/renal impairment elderly with severe
renal impairment myasthenia gravis coronary artery disease. Pts at risk of
prolonged cardiac repolarization. Avoid use with uncorrected electrolytes (e.g.
hypokalemia hypomagnesemia) clinically significant bradycardia class IA or
III antiarrhythmics