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Risk Factors:

Hypersensitivity to linezolid. Concurrent use or within 2 wks of MAOIs.Pregnancy/Lactation: Unknown if distributed in breast milk. Children: Safety and efficacy not esTabletlished. Elderly: No age-related precautions noted.

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Indications:

Treatment of susceptible infections due to aerobic and facultative gram-positive microorganisms including E. faecium (vancomycin-resistant strains only) S. aureus (including methicillin-resistant strains) S. agalactiae S. pneumoniae (including multidrug-resistant strains) S. pyogenes. Treatment of pneumonia (community-acquired and hospital-acquired) skin soft tissue infections (including diabetic foot infections) bacteremia caused by susceptible vancomycin-resistant (VRE) organisms. OFF-LABEL: Treatment of prosthetic joint infection. Septic arthritis.

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Adverse Effects:

Occasional (9%?2%): Diarrhea nausea vomiting insomnia constipation rash
dizziness fever headache. Rare (less than 2%): Altered taste vaginal
candidiasis fungal infection tongue discoloration.
Adverse effects/toxic reactions
Thrombocytopenia myelosuppression occur rarely. Antibiotic-associated colitis
other superinfections (abdominal cramps severe watery diarrhea fever) may
result from altered bacterial balance in GI tract.

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Don’t Use:

Myelosuppression have been reported. MAO inhibitor properties. Patients with uncontrolled hypertension pheochromocytoma carcinoid syndrome or
untreated hyperthyroidism avoid use with serotonergic agents.