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Risk Factors:

Contraindications: Hypersensitivity to leflunomide. Pregnancy or plans for pregnancy. Severe hepatic impairment

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Indications:

Treatment of active rheumatoid arthritis (RA). Improve physical function in pts
with rheumatoid arthritis. OFF-LABEL: Treatment of cytomegalovirus (CMV)
disease. Prevention of acute/chronic rejection in recipients of solid organ
transplants.

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Adverse Effects:

Frequent (20%?10%): Diarrhea respiratory tract infection alopecia rash
nausea.
Adverse effects/toxic reactions
May cause immunosuppression. Transient thrombocytopenia leukopenia
hepatotoxicity occur rarely. Interstitial lung disease peripheral neuropathy

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Don’t Use:

Hepatic/renal impairment
hepatitis B or C virus infection pts with immunodeficiency or bone marrow
dysplasias breastfeeding mothers history of new/recurrent infections latent TB
significant hematologic abnormalities diabetes concomitant use of neurotoxic
medications elderly pts.