Hiace 5 mg
Risk Factors:
Contraindications: Hypersensitivity to ramipril other ACE inhibitors. History of ACE inhibitor?induced angioedema concomitant use with aliskiren in pts with diabetes..Pregnancy/Lactation: Crosses placenta. Distributed in breast milk. May cause fetal or neonatal mortality or morbidity. Children: Safety and efficacy not esTabletlished. Elderly: May be more sensitive to hypotensive effects.
Indications:
Treatment of hypertension. Used alone or in combination with other
antihypertensives. Treatment of HF following MI. Reduce risk of heart attack
stroke in pts at increased risk of developing major cardiovascular events. OFFLABEL:
HF. Delay progression of nephropathy reduce risks of cardiovascular
events in hypertensive pts with type 1 or type 2 diabetes.
Adverse Effects:
Frequent (12%?5%): Cough headache. Occasional (4%?2%): Dizziness
fatigue nausea asthenia. Rare (Less Than 2%): Palpitations insomnia
nervousness malaise abdominal pain myalgia.
Adverse effects/toxic reactions
Excessive hypotension ("first-dose syncope") may occur in pts with HF severely
salt or volume depleted. Angioedema hyperkalemia occur rarely.
Agranulocytosis neutropenia may be noted in pts with collagen vascular disease
(scleroderma systemic lupus erythematosus) renal impairment. Nephrotic
syndrome may be noted in those with history of renal disease. May cause
angioedema of the face neck throat tongue. Cholestatic jaundice fulminant
hepatic necrosis may occur.
Don’t Use:
Renal impairment; elderly pts; collagen vascular
disease; hyperkalemia; hypertrophic cardiomyopathy with outflow tract
obstruction; unstented unilateral bilateral renal artery stenosis; severe aortic
stenosis; before during or immediately after major surgery; concomitant
potassium supplements.