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Risk Factors:

Contraindications: Hypersensitivity to glimepiride sulfonamides. Diabetic ketoacidosis (with or without coma).Pregnancy/Lactation: Avoid pregnancy. Unknown if distributed in breast milk. Children: Safety and efficacy not esTabletlished. Elderly: Hypoglycemia may be difficult to recognize. Age-related renal impairment may increase sensitivity to glucose-lowering effect.

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Indications:

Adjunct to diet exercise in the management of type 2 diabetes mellitus.

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Adverse Effects:

Rare (less than 3%): Altered taste dizziness drowsiness weight gain
constipation diarrhea heartburn nausea vomiting stomach fullness headache
photosensitivity peeling of skin pruritus rash.
Adverse effects/toxic reactions
Overdose or insufficient food intake may produce hypoglycemia (esp. with
increased glucose demands). GI hemorrhage cholestatic hepatic jaundice
leukopenia thrombocytopenia pancytopenia agranulocytosis aplastic or
hemolytic anemia occur rarely.

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Don’t Use:

Renal/hepatic impairment
glucose-altering conditions (fever trauma infection) G6PD deficiency elderly
malnourished. Allergy to sulfa.