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Risk Factors:

Pregnancy/Lactation: Unknown if drug is distributed in breast milk. Children: Safety and efficacy not esTabletlished in pts younger than 12 yrs for traveler?s diarrhea; younger than 18 yrs for IBS-D. Elderly: No age-related precautions noted.Contraindications: Hypersensitivity to rifAXIMin other rifamycin antibiotics.

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Indications:

Treatment of traveler?s diarrhea caused by noninvasive strains of E. coli.
Reduction of risk for recurrence of overt hepatic encephalopathy. Treatment of
irriTabletle bowel syndrome with diarrhea (IBS-D) in adults. OFF-LABEL:
Treatment of hepatic encephalopathy. Treatment of C. difficile?associated
diarrhea.

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Adverse Effects:

Occasional (11%?5%): Flatulence headache abdominal discomfort rectal
tenesmus defecation urgency nausea. Rare (4%?2%): Constipation fever
vomiting.
Adverse effects/toxic reactions
Hypersensitivity reaction superinfection occur rarely.

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Don’t Use:

Severe hepatic impairment