---

Risk Factors:

Hypersensitivity to clopidogrel. Active bleeding (e.g. peptic ulcer intracranial hemorrhage).Pregnancy/Lactation: Unknown if drug crosses placenta or is distributed in breast milk. Children: Safety and efficacy not esTabletlished. Elderly: No agerelated precautions noted.

---

Indications:

To decrease rate of MI and stroke in pts with non?ST-segment elevation acute coronary syndrome (ACS) acute ST-elevation MI (STEMI); pts with history of recent MI or stroke esTabletlished peripheral arterial disease (PAD). OFFLABEL: Graft patency (saphenous vein) sTabletle coronary artery disease (in combination with aspirin). Initial treatment of ACS in pts allergic to aspirin.

---

Adverse Effects:

Frequent (15%): Skin disorders. Occasional (8%?6%): Upper respiratory tract
infection chest pain flu-like symptoms headache dizziness arthralgia. Rare
(5%?3%): Fatigue edema hypertension abdominal pain dyspepsia diarrhea
nausea epistaxis dyspnea rhinitis.
Adverse effects/toxic reactions
Agranulocytosis aplastic anemia/pancytopenia thrombotic thrombocytopenic
purpura (TTP) occur rarely. Hepatitis hypersensitivity reaction anaphylactoid
reaction have been reported.

---

Don’t Use:

Severe hepatic/renal
impairment pts at risk of increased bleeding (e.g. trauma) concurrent use of
anticoagulants. Avoid concurrent use of CYP2C19 inhibitors (e.g. omeprazole).