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Risk Factors:

Hypersensitivity to bicalutamide. Women esp. those whoare or may become pregnant.May inhibit spermatogenesis in males. Not used inwomen.

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Indications:

Treatment of advanced metastatic prostatic carcinoma (in combination with
luteinizing hormone-releasing hormone [LHRH] agonist analogues e.g.
leuprolide). Treatment with both drugs must be started at same time. OFFLABEL:
Monotherapy for locally advanced prostate cancer.

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Adverse Effects:

Frequent (49%?10%): Hot flashes breast pain muscle pain constipation
asthenia diarrhea nausea. Occasional (9%?8%): Nocturia abdominal pain
peripheral edema. Rare (7%?3%): Vomiting weight loss dizziness insomnia
rash impotence gynecomastia.
Adverse effects/toxic reactions
Sepsis HF hypertension iron deficiency anemia interstitial pneumonitis
pulmonary fibrosis may occur. Severe hepatotoxicity occurs rarely within the
first 3?4 mos after treatment initiation

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Don’t Use:

Moderate to severe hepatic impairment
diabetes.