Casodex 50 mg
Hypersensitivity to bicalutamide. Women esp. those whoare or may become pregnant.May inhibit spermatogenesis in males. Not used inwomen.
Treatment of advanced metastatic prostatic carcinoma (in combination with
luteinizing hormone-releasing hormone [LHRH] agonist analogues e.g.
leuprolide). Treatment with both drugs must be started at same time. OFFLABEL:
Monotherapy for locally advanced prostate cancer.
Frequent (49%?10%): Hot flashes breast pain muscle pain constipation
asthenia diarrhea nausea. Occasional (9%?8%): Nocturia abdominal pain
peripheral edema. Rare (7%?3%): Vomiting weight loss dizziness insomnia
rash impotence gynecomastia.
Adverse effects/toxic reactions
Sepsis HF hypertension iron deficiency anemia interstitial pneumonitis
pulmonary fibrosis may occur. Severe hepatotoxicity occurs rarely within the
first 3?4 mos after treatment initiation
Moderate to severe hepatic impairment