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Risk Factors:

Contraindications: Hypersensitivity to raNITIdine. OTC: Do not use if trouble or pain when swallowing food vomiting with blood or bloody or black stool is present. Do not use 150 mg with kidney disease (unless medically advised).Pregnancy/Lactation: Unknown if drug crosses placenta or is distributed in breast milk. Children: No age-related precautions noted. Elderly: Confusion more likely with hepatic/renal impairment.

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Indications:

Short-term treatment of active duodenal ulcer. Prevention of duodenal ulcer
recurrence. Treatment of active benign gastric ulcer pathologic GI
hypersecretory conditions acute gastroesophageal reflux disease (GERD)
including erosive esophagitis. Maintenance of healed erosive esophagitis. OTC:
Relief of heartburn acid indigestion sour stomach. OFF-LABEL: Treatment of
upper GI bleeding. Prevention of stress-induced ulcers in ICU. Anaphylaxis
(adjunct therapy). Premedication to prevent taxane hypersensitivity.

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Adverse Effects:

Occasional (2%): Diarrhea. Rare (1%): Constipation headache (may be
severe).
Adverse effects/toxic reactions
Reversible hepatitis blood dyscrasias occur rarely.

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Don’t Use:

Renal/hepatic impairment elderly pts history of acute porphyria.